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- Title
结构简单的4-羟基脯氨酰胺高效催化醛和硝基烯不对称 迈克尔加成反应.
- Authors
成燕琴; 黎卓熹; 王有娣; 徐娟娟; 卞 证
- Abstract
The structurally simplified trans-4-hydroxy-L-prolinamide derivatives are prepared as the efficient organocatalysts for Michael-type asymmetric reactions. Their catalytic behaviors are evaluated in the asymmetric Michael addition of aldehydes to nitroolefins with (S)-1,1'-bi-2-naphthol as the co-catalyst. Excellent diastereoand enantioselectivities(respectively up to >99/1 and 99%), as well as high yields(up to 96%)are achieved even at the catalyst loading of as low as 0. 5%~1%(molar percent). This study provides a facile method to develop the low-cost and highly efficient organocatalyst system for the asymmetric Michael addition reactions.
- Subjects
MICHAEL reaction; ALDEHYDES; NITROALKENES; CATALYSTS; CATALYSIS
- Publication
Chinese Journal of Applied Chemistry, 2023, Vol 40, Issue 1, p146
- ISSN
1000-0518
- Publication type
Article
- DOI
10.19894/j.issn.1000-0518.220155