We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cognitive dysfunction after cardiac surgery: revisiting etiology.
- Authors
Grocott, Hilary P.; Homi, H. Mayumi; Puskas, Ferenc
- Abstract
Cognitive dysfunction remains a frequent complication of cardiac surgery. Despite many years of research, few preventive strategies and no definitive therapeutic options exist for the management of this troublesome clinical problem. This shortcoming may be secondary to an incomplete understanding of the pathophysiology and etiology of cognitive loss after cardiac surgery; a better understanding of the etiology is essential to finding new therapies. The etiology of cognitive dysfunction after cardiac surgery is multifactorial and includes cerebral microembolization, global cerebral hypoperfusion, systemic and cerebral inflammation, cerebral temperature perturbations, cerebral edema, and possible blood-brain barrier dysfunction, all superimposed on genetic differences in patients that may make them more susceptible to injury or unable to repair from injury once it has occurred. This review expands on these potential etiologies in detailing the evidence for their existence.
- Subjects
COGNITION disorders; CARDIAC surgery; SURGICAL complications; BRAIN injuries; MEDICINE; BLOOD-brain barrier; ENCEPHALITIS; CEREBRAL circulation; CEREBRAL edema; CEREBRAL embolism &; thrombosis; CEREBROVASCULAR disease; THERMOTHERAPY; PSYCHOLOGICAL factors; PSYCHOLOGY; PREVENTION; PHYSIOLOGY
- Publication
Seminars in Cardiothoracic & Vascular Anesthesia, 2005, Vol 9, Issue 2, p123
- ISSN
1089-2532
- Publication type
journal article
- DOI
10.1177/108925320500900204