We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Genome destabilization by homologous recombination in the germ line.
- Authors
Sasaki, Mariko; Lange, Julian; Keeney, Scott
- Abstract
Meiotic recombination, which promotes proper homologous chromosome segregation at the first meiotic division, normally occurs between allelic sequences on homologues. However, recombination can also take place between non-allelic DNA segments that share high sequence identity. Such non-allelic homologous recombination (NAHR) can markedly alter genome architecture during gametogenesis by generating chromosomal rearrangements. Indeed, NAHR-mediated deletions, duplications, inversions and other alterations have been implicated in numerous human genetic disorders. Studies in yeast have provided insights into the molecular mechanisms of meiotic NAHR as well as the cellular strategies that limit it.
- Subjects
GENOMES; GENETIC recombination; ANTIBODY diversity; MEIOSIS; NUCLEOTIDE sequence; GENETIC disorders
- Publication
Nature Reviews Molecular Cell Biology, 2010, Vol 11, Issue 3, p182
- ISSN
1471-0072
- Publication type
Article
- DOI
10.1038/nrm2849