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- Title
Fc?RIIB gene polymorphisms in Japanese periodontitis patients.
- Authors
Yasuda, K.; Sugita, N.; Kobayashi, T.; Yamamoto, K.; Yoshie, H.
- Abstract
Human type II low-affinity receptor for immunoglobulin G (Fc?RII) constitutes a clustered gene family consisting of Fc?RIIA, IIB and IIC genes. Fc?RIIB is unique in its ability to transmit inhibitory signals in B cells via immunoreceptor tyrosine-based inhibitory motif (ITIM). B-cell activation and subsequent elevated production of IgG are the immunopathological features of inflammatory disease such as periodontitis. To determine whether an association with periodontitis susceptibility exists, genetic polymorphisms of Fc?RIIB were examined in Japanese patients with aggressive periodontitis (AGP) and chronic periodontitis (CP), and in the race-matched healthy controls (HCs). A significant difference was observed in the distribution of Fc?RIIB-232I/T allele (exon 5) between the AGP and HC groups, with enrichment of the 232T in the AGP group (P=0.006). In addition, the Fc?RIIB-nt 646-184A/G allele (intron 4) distribution was significantly different between the CP and HC groups, with enrichment of the nt 646-184A in the CP group (P=0.011). These results document the association of Fc?RIIB gene polymorphisms with susceptibility to periodontitis in the Japanese.Genes and Immunity (2003) 4, 541-546. doi:10.1038/sj.gene.6364021
- Subjects
JAPAN; PERIODONTITIS; PERIODONTAL disease; IMMUNOLOGY of inflammation; GENETICS of disease susceptibility; GENETIC polymorphisms; IMMUNOGLOBULIN G; B cells; MEDICAL genetics; PHYSIOLOGY
- Publication
Genes & Immunity, 2003, Vol 4, Issue 8, p541
- ISSN
1466-4879
- Publication type
Article
- DOI
10.1038/sj.gene.6364021