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- Title
miR-20b promotes growth of non-small cell lung cancer through a positive feedback loop of the Wnt/β-catenin signaling pathway.
- Authors
Ren, Tao; Fan, Xing-Xing; Wang, Mei-Fang; Duan, Fu-Gang; Wei, Chun-Li; Li, Run-Ze; Jiang, Ze-Bo; Wang, Yu-Wei; Yao, Xiao-Jun; Chen, Ming-Wei; Tang, Yi-Jun; Leung, Elaine Lai-Han
- Abstract
microRNAs (miRNAs or miRs) are endogenous noncoding single-stranded RNA molecules that can regulate gene expression by targeting the 3′-untranslated region and play an important role in many biological and pathological processes, such as inflammation and cancer. In this study, we found that miR-20b was significantly increased in human non-small cell lung cancer (NSCLC) cell lines and patient tissues, suggesting that it may possess a carcinogenic role in lung cancer. This miRNA promoted the proliferation, migration and invasion of NSCLC cells by targeting and downregulating the expression of adenomatous polyposis coli (APC), which is a negative regulator of the canonical Wnt signaling pathway. Wnt signaling activation may increase transcription of miR-20b. Therefore, miR-20b and canonical Wnt signaling were coupled through a feed-forward positive feedback loop, forming a biological regulatory circuit. Finally, an in vivo investigation further demonstrated that an increase in miR-20b promoted the growth of cancer cells. Overall, our findings offer evidence that miR-20b may contribute to the development of NSCLC by inhibiting APC via the canonical Wnt signaling pathway.
- Publication
International Journal of Oncology, 2020, Vol 56, Issue 2, p470
- ISSN
1019-6439
- Publication type
Article
- DOI
10.3892/ijo.2019.4940