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- Title
Emerging Properties and Functional Consequences of Noncoding Transcription.
- Authors
Ard, Ryan; Allshire, Robin C.; Marquardt, Sebastian
- Abstract
Eukaryotic genomes are rich in transcription units encoding "long noncoding RNAs" (lncRNAs). The purpose of all this transcription is unclear since most lncRNAs are quickly targeted for destruction during synthesis or shortly thereafter. As debates continue over the functional significance of many specific lncRNAs, support grows for the notion that the act of transcription rather than the RNA product itself is functionally important in many cases. Indeed, this alternative mechanism might better explain how lowabundance lncRNAs transcribed from noncoding DNA function in organisms. Here, we highlight some of the recently emerging features that distinguish coding from noncoding transcription and discuss how these differences might have important implications for the functional consequences of noncoding transcription.
- Subjects
EUKARYOTIC genomes; NON-coding RNA; CHEMICAL synthesis; NON-coding DNA; GENETIC regulation
- Publication
Genetics, 2017, Vol 207, Issue 2, p357
- ISSN
0016-6731
- Publication type
Article
- DOI
10.1534/genetics.117.300095