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- Title
Obesity Upregulates Genes Involved in Oxidative Phosphorylation in Livers of Diabetic Patients.
- Authors
Takamura, Toshinari; Misu, Hirofumi; Matsuzawa-Nagata, Naoto; Sakurai, Masaru; Ota, Tsuguhito; Shimizu, Akiko; Kurita, Seiichiro; Takeshita, Yumie; Ando, Hitoshi; Honda, Masao; Kaneko, Shuichi
- Abstract
The article discusses a study on the possible molecular structures of obesity and the clinical significance of oxidative phosphorylation (OXPHOS) gene expression in the livers of type 2 diabetics. The modified gene expression involved in mitochondrial OXPHOS has been considered as a key change in insulin-sensitive organs of such patients. The researchers observed that pathophysiology of type 2 diabetes is affected by obesity by upregulating genes involved in OXPHOS.
- Subjects
MOLECULAR structure; OBESITY genetics; GENE expression; PEOPLE with diabetes; PATHOLOGICAL physiology
- Publication
Obesity (19307381), 2008, Vol 16, Issue 12, p2601
- ISSN
1930-7381
- Publication type
Article
- DOI
10.1038/oby.2008.419