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- Title
Morphological and Biochemical Changes Associated with Apoptosis Induced by Okadaic Acid in Human Amniotic FL Cells.
- Authors
Ming-Luan Xing; Xiao-Feng Wang; Xin Zhu; Xu-Dong Zhou; Li-Hong Xu
- Abstract
The article presents a study on the morphological and biochemical changes linked with apoptosis induced by okadaic acid (OA) in human amniotic FL cells. The study focuses on the determination of the toxic effects of OA in FL cells with relatively lower concentrations and shorter incubation time. Changes in the morphological and biochemical components of FL cells were examined, as cells were induced by OA. Findings on the study show that phosphatidylserine externalization, cytoskeletal disruption, breakage of DNA strand, decreased of Bcl-2 protein experience levels, and PP2A-A subunit protein increase were all associated in the apoptosis of FL cells induced by OA.
- Subjects
CELLS; APOPTOSIS; CELL death; DNA; CELL-mediated cytotoxicity; PHOSPHATIDYLSERINES; PROTEIN synthesis; NUCLEIC acids; CYTOLOGICAL research
- Publication
Environmental Toxicology, 2009, Vol 24, Issue 5, p437
- ISSN
1520-4081
- Publication type
Article
- DOI
10.1002/tox.20446