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- Title
Molecular structures of two copper complexes with the pharmaceuticals norfloxacin and tinidazole, when powder X-ray diffraction assists multi-domain single-crystal X-ray diffraction.
- Authors
Tobón Zapata, Gloria Elena; Martínez Carmona, Dina Marcela; Alberto Echeverría, Gustavo; Piro, Oscar Enrique
- Abstract
The crystal structures of bis[1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-ium-4-yl)-1,4- dihydroquinoline-3-carboxylato]copper(II) sulfate heptahydrate, [Cu(C16H18FN3O3) 2]SO4.7H2O or [Cu(nor)2]SO4.7H2O (nor is norfloxacin), and bis{1-[2- (ethylsulfonyl)ethyl]-2-methyl-5-nitroimide}dinitratocopper(II), [Cu(NO3)2- (C8H13N3O4S)2] or [Cu(NO3)2(tnz)2] (tnz is tinidazole), were solved by X-ray diffraction. Both complexes crystallize in the space group P21/c, with Z = 4 (for nor) and Z = 2 (for ntz) molecules per unit cell. In [Cu(nor)2]SO4.7H2O, the CuII ion is at the centre of a square-planar environment, trans coordinated to two independent norfloxacin molecules in the zwitterionic form acting as bidentate ligands through one of the carboxyl (cbx) and the carbonyl (cb) O atoms. The solid is further stabilized by an extensive network of N--H. . .O(sulfate), N--H. . .O(cbx), N--H. . .OW, OW--H. . .O(sulfate) and OW--H. . .OW hydrogen bonds. The [Cu(NO3)2(tnz)2] complex is centrosymmetric, with the CuII ion in a square planar environment, coordinated to a tinidazole molecule acting as a monodentate ligand through its imidazole N atom and to one nitrate O atom. The vibrational FT-IR absorption spectra and thermal behaviour of the complexes were also studied and are briefly discussed based on the crystal structures.
- Subjects
NORFLOXACIN; X-ray powder diffraction; MOLECULAR structure; X-ray diffraction; COPPER compounds; COPPER powder; ATOMS; ABSORPTION spectra
- Publication
Acta Crystallographica Section B: Structural Science, Crystal Engineering & Materials, 2022, Vol 78, Issue 3, Part 1, p490
- ISSN
2052-5192
- Publication type
Article
- DOI
10.1107/S2052520622003766