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- Title
RNA-based gene delivery system hidden in breast milk microvesicles.
- Authors
Kemal Irmak, M.; Oztas, Yesim; Oztas, Emin
- Abstract
Human milk samples contain microvesicles similar to the retroviruses. These microvesicles contain single-stranded RNA and possess reverse transcriptase activity. It has recently been reported that RNA content of the microvesicles could be transferred to other cells and be functional in their new location. These microvesicles may therefore transfer genetic signals from mother to neonate during breastfeeding. Moreover, transfer of wild type RNA from a healthy wet-nurse to the suckling neonate through the milk microvesicles and its subsequent reverse transcription and integration into the neonate genome could result in permanent correction of the clinical manifestations in genetic diseases
- Subjects
BREAST milk; RETROVIRUSES; RNA; GENOMES; GENETIC disorders
- Publication
Journal of Experimental & Integrative Medicine, 2012, Vol 2, Issue 2, p125
- ISSN
1309-4572
- Publication type
Article
- DOI
10.5455/jeim.150312.hp.003