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- Title
Raloxifene inhibits hepatitis C virus infection and replication.
- Authors
Takeda, Midori; Ikeda, Masanori; Mori, Kyoko; Yano, Masahiko; Ariumi, Yasuo; Dansako, Hiromichi; Wakita, Takaji; Kato, Nobuyuki
- Abstract
Postmenopausal women with chronic hepatitis C exhibited a poor response to interferon (IFN) therapy compared to premenopausal women. Osteoporosis is the typical complication that occurs in postmenopausal women. Recently, it was reported that an osteoporotic reagent, vitamin D3, exhibited anti‐hepatitis C virus (HCV) activity. Therefore, we investigated whether or not another osteoporotic reagent, raloxifene, would exhibit anti‐HCV activity in cell culture systems. Here, we demonstrated that raloxifene inhibited HCV RNA replication in genotype 1b and infection in genotype 2a. Raloxifene enhanced the anti‐HCV activity of IFN‐α. These results suggest a link between the molecular biology of osteoporosis and the HCV life cycle.
- Subjects
RALOXIFENE; HEPATITIS C virus; VIRAL replication; OSTEOPOROSIS in women; THERAPEUTIC use of interferons
- Publication
FEBS Open Bio, 2012, Vol 2, Issue 1, p279
- ISSN
2211-5463
- Publication type
Article
- DOI
10.1016/j.fob.2012.08.003