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- Title
Use of nested polymerase chain reaction (PCR) for detection of retroviruses from formalin-fixed, paraffin-embedded uveal melanomas in cats.
- Authors
Stiles; Bienzle; Render; Buyukmihci; Johnson
- Abstract
Thirty-six formalin-fixed, paraffin-embedded enucleated globes from cats with a diagnosis of diffuse anterior uveal melanoma were obtained. Sections of tumor were excised, deparaffinized, and subjected to nested polymerase chain reaction (PCR) to identify proviral DNA sequences from the feline leukemia virus (FeLV)-feline sarcoma virus (FeSV; 36 eyes), and the feline immunodeficiency virus (FIV; 18 eyes). All samples tested were negative for FIV DNA. Three samples were positive for FeLV-FeSV DNA. This is the first reported evidence of a possible link between naturally occurring feline anterior uveal melanoma and the presence of FeLV-FeSV DNA.
- Subjects
FELINE leukemia virus; FELINE sarcoma virus; FELINE immunodeficiency virus
- Publication
Veterinary Ophthalmology, 1999, Vol 2, Issue 2, p113
- ISSN
1463-5216
- Publication type
Article
- DOI
10.1046/j.1463-5224.1999.00066.x