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- Title
Human T-lymphotropic Virus 1 (HTLV-1) infection - dermatological implications.
- Authors
Amano, Masahiro; Setoyama, Mitsuru; Grant, Annika; Kerdel, Francisco A.
- Abstract
Human T-lymphotropic virus type 1 (HTLV-1) is a type C retrovirus primarily endemic to Japan, Central and South America, the Middle East, regions of Africa, and the Caribbean. Currently, an estimated 10-20 million people worldwide are infected with this virus. Although the majority of infected individuals remain asymptomatic, HTLV-1 is the causative agent of a number of disorders, notably adult T-cell leukemia/lymphoma (ATLL) and a progressive demyelinating neurological disorder, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In addition to ATLL and HAM/TSP, HTLV-1 has been associated with a spectrum of skin disorders, such as infective dermatitis associated with HTLV-1, crusted scabies, and leprosy. The understanding of the interaction between virus and host response has improved markedly, but there are still few treatment options.
- Subjects
HTLV-I; HTLV diseases; ADULT T-cell leukemia; PARAPARESIS; SCABIES; HANSEN'S disease; DISEASE risk factors
- Publication
International Journal of Dermatology, 2011, Vol 50, Issue 8, p915
- ISSN
0011-9059
- Publication type
Article
- DOI
10.1111/j.1365-4632.2011.04882.x