We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Brain Region- and Age-Dependent 5-Hydroxymethylcytosine Activity in the Non-Human Primate.
- Authors
Yanru Xu; Liying Zhong; Huixian Wei; Yuwei Li; Jiaxiang Xie; Leijie Xie; Xiusheng Chen; Xiangyu Guo; Peng Yin; Shihua Li; Junwei Zeng; Xiao-Jiang Li; Li Lin
- Abstract
Because of the difficulty in collecting fresh brains of humans at different ages, it remains unknown how epigenetic regulation occurs in the primate brains during aging. In the present study, we examined the genomic distribution of 5hmC, an indicator of DNA methylation, in the brain regions of non-human primates (rhesus monkey) at the ages of 2 (juvenile), 8 (young adult), and 17 (old) years. We found that genomic 5hmC distribution was accumulated in the monkey brain as age increased and displayed unique patterns in the cerebellumand striatumin an age-dependentmanner. We also observed a correlation between differentially hydroxymethylated regions (DhMRs) and genes that contribute to brain region-related functions and diseases. Our studies revealed, for the first time, the brain-region and age-dependent 5hmC modifications in the non-human primate and the association of these 5hmC modifications with brain region-specific function and potentially aging-related brain diseases.
- Subjects
RNA analysis; DNA analysis; BRAIN metabolism; RISK factors of neurodegeneration; HIPPOCAMPUS (Brain); SEQUENCE analysis; AGE distribution; HETEROCYCLIC compounds; ANIMAL experimentation; PRIMATES; DNA methylation; CEREBELLUM; IMMUNOBLOTTING; AGING; RESEARCH funding; DESCRIPTIVE statistics; TRANSGENIC animals; AMYGDALOID body; EPIGENOMICS; CEREBRAL cortex; ALGORITHMS
- Publication
Frontiers in Aging Neuroscience, 2022, Vol 14, p1
- ISSN
1663-4365
- Publication type
Article
- DOI
10.3389/fnagi.2022.934224