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- Title
Endogenous amdoparvovirus-related elements reveal insights into the biology and evolution of vertebrate parvoviruses.
- Authors
Pénzes, Judit J; Marsile-Medun, Soledad; Agbandje-McKenna, Mavis; Gifford, Robert James
- Abstract
Amdoparvoviruses (family Parvoviridae: genus Amdoparvovirus) infect carnivores, and are amajor cause ofmorbidity andmortality in farmed animals. In this study, we systematically screened animal genomes to identify endogenous parvoviral elements (EPVs) disclosing a high degree of similarity to amdoparvoviruses, and investigated their genomic, phylogenetic and protein structural features. We report the first examples of full-length, amdoparvovirus-derived EPVs in the genome of the Transcaucasianmole vole (Ellobius lutescens). We also identify four EPVs inmammal and reptile genomes that are intermediate between amdoparvoviruses and their sister genus (Protoparvovirus) in terms of their phylogenetic placement and genomic features. In particular, we identify a genome-length EPV in the genome of a pit viper (Protobothrops mucrosquamatus) that ismore similar to a protoparvovirus than an amdoparvovirus in terms of its phylogenetic placement and the structural features of its capsid protein (as revealed by homologymodeling), yet exhibits characteristically amdoparvovirus-like genome features including: (1) a putativemiddle ORF gene; (2) a capsid gene that lacks a phospholipase A2 domain; (3) a genome structure consistent with an amdoparvovirus-likemechanismof capsid gene expression. Our findings indicate that amdoparvovirus host range extends to rodents, and that parvovirus lineages possessing amixture of proto- and amdoparvovirus-like characteristics have circulated in the past. In addition, we show that EPV sequences in themole vole and pit viper encode intact, expressible replicase genes that have potentially been co-opted or exapted in these host species.
- Subjects
CIRCULATING anticoagulants; ENDOGENOUS retroviruses; NEUROVIROLOGY; CAPSIDS; GENETIC engineering; GENOMICS
- Publication
Virus Evolution, 2018, Vol 4, Issue 2, p1
- ISSN
2057-1577
- Publication type
Article
- DOI
10.1093/ve/vey026