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- Title
Ovarian Carcinoma: Recent Developments in Classification of Tumour Histological Subtype.
- Authors
Clarke, Blaise A.; Gilks, Blake
- Abstract
Histological types of ovarian carcinomas are distinct entities with different molecular and immunohistochemical profiles and clinical outcomes. The implementation of subtype-specific therapies for subtypes of ovarian cancer requires reproducible histological diagnoses. More than 95% of ovarian carcinomas can be reproducibly diagnosed as one of five histological types, in descending order of frequency: high-grade serous carcinoma, clear cell carcinoma, endometrioid carcinoma, mucinous carcinoma, and low-grade serous carcinoma. There are occasional cases of mixed histological type, and rare cases defy classification (adenocarcinoma not otherwise specified [NOS], or unclassifiable). Alihough immunohistochemical markers are a useful adjunct for the assignment of histological type, by using the modified definitions presented in this review, the majority of ovarian carcinomas can be reliably assigned to a category without recourse to immunohistochemistry.
- Subjects
OVARIAN cancer; HISTOLOGY; ADENOCARCINOMA; RENAL cell carcinoma; ENDOMETRIOSIS
- Publication
Canadian Journal of Pathology, 2011, Vol 3, Issue 3, p33
- ISSN
1918-915X
- Publication type
Article