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- Title
A Bench‐stable 8‐Aminoquinoline Derived Phosphine‐free Manganese (I)‐Catalyst for Environmentally Benign C(α)‐Alkylation of Oxindoles with Secondary and Primary Alcohols.
- Authors
Saini, Parul; Dolui, Pritam; Nair, Abhishek; Verma, Ashutosh; Elias, Anil J.
- Abstract
Herein, we report a new air‐stable phosphine‐free 8‐AQ (8‐aminoquinoline) based Mn(I) carbonyl complex as the catalyst for the C(α)‐alkylation of oxindoles with alcohols. The Mn complex [(8‐AQ)Mn(CO)3Br] works effectively as a catalyst for the α‐alkylation of oxindoles by both secondary as well as primary alcohols. The procedure has been used for the synthesis of pharmaceutically important recently developed oxindoles such as 3‐(4‐methoxybenzyl)indolin‐2‐one, 3‐(4‐(dimethylamino)benzyl)indolin‐2‐one, 3‐(4‐(dimethylamino)phenyl)‐5‐fluoroindolin‐2‐one and 3‐(benzo[d][1,3]dioxol‐5‐ylmethyl)indolin‐2‐one, which are found to be effective in preventing specific types of cell death in neurodegenerative disorders. Control experiments have been carried out to investigate the reaction mechanism and the crucial role of metal‐ligand cooperation via ‐NH2 moiety during catalysis.
- Subjects
OXINDOLES; ALCOHOL; MANGANESE; NEURODEGENERATION; CELL death
- Publication
Chemistry - An Asian Journal, 2023, Vol 18, Issue 6, p1
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.202201148