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- Title
Carbapenem-Resistant Pseudomonas aeruginosa Spondylodiscitis Treated with Ceftazidime-Avibactam: A Case Report with Literature Review.
- Authors
da Nóbrega Danda, Guilherme José; Franco, Andreia Craveiro; Gomes, Elisangela Ana Paula; Montanaro, Vinícius Vianna Abreu; Martins, Bernardo José Alves Ferreira; Aguiar, Vitor Viana Bonan de
- Abstract
Pyogenic spondylodiscitis (PS) is a highly morbid and potentially fatal bacterial infection with an increasing incidence in recent decades. Its diagnosis and treatment are challenging, especially with the expansion of multidrug- or extensively drug-resistant bacteria. We report a rare case of PS caused by carbapenem-resistant Pseudomonas aeruginosa (CRPA) that was treated with ceftazidime-avibactam (C/A). The choice of C/A therapy was based on the patient's bacterial sensitivity profile and intolerance to the initial therapeutic regimen (polymyxin B and meropenem). The total antimicrobial treatment time was seven weeks. The evolution of the clinical course met the cure criteria, which was characterized by remission of signs and symptoms, normalization of inflammatory markers, and radiological improvement over 18 months of clinical follow-up. This is a rare case of CRPA spondylodiscitis that responded to C/A treatment.
- Subjects
CARBAPENEM-resistant bacteria; LITERATURE reviews; SPONDYLODISCITIS; POLYMYXIN B; SYMPTOMS; MICROCYSTIS aeruginosa
- Publication
Infection & Drug Resistance, 2023, Vol 16, p5309
- ISSN
1178-6973
- Publication type
Article
- DOI
10.2147/IDR.S421209