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- Title
Absence of Degradation of Tretinoin When Benzoyl Peroxide is Combined with an Optimized Formulation of Tretinoin Gel (0.05%).
- Authors
DEL ROSSO, JAMES Q.; PILLAI, RADHAKRISHNAN; MOORE, ROBERT
- Abstract
<bold>Background: </bold>Clinicians have been reluctant to prescribe benzoyl peroxide concurrently with topical tretinoin due to a belief that the benzoyl peroxide may cause oxidation and degradation of the tretinoin molecule, thereby reducing its effectiveness. However, benzoyl peroxide-induced degradation of tretinoin may not necessarily apply to all topical tretinoin formulations.<bold>Objective: </bold>To evaluate the potential for benzoyl peroxide-induced degradation of an optimized aqueous gel formulation of tretinoin (0.05%).<bold>Methods: </bold>Tretinoin gel (0.05%) and benzoyl peroxide gel (6.26% premix concentration to produce 5% benzoyl peroxide in a fixed combination clindamycin product) were mixed together (1:1) at 32ºC and samples assayed after 1, 2, 3, 5, and 7 hours. Each sample was analyzed for tretinoin (expressed as % tretinoin remaining) and its degradation product content.<bold>Results: </bold>No loss of tretinoin was observed over the seven-hour time period. When tretinoin gel (0.05%) was combined with benzoyl peroxide, 100 percent of the initial tretinoin concentration remained after seven hours. There was no increase in the degradation products of tretinoin.<bold>Conclusions: </bold>There was no benzoyl peroxide-induced degradation of tretinoin when the optimized formulation of tretinoin gel (0.05%) was admixed with benzoyl peroxide gel (6.26%). Although the direct clinical significance of these results is unknown, clinicians may feel comfortable using this particular combination concurrently without concerns about tretinoin oxidation and degradation.
- Subjects
TRETINOIN; DERMATOLOGIC agents; ACNE; SKIN disease treatment; PEROXIDES; OXIDATION; ANTIBIOTICS
- Publication
Journal of Clinical & Aesthetic Dermatology, 2010, Vol 3, Issue 10, p26
- ISSN
1941-2789
- Publication type
journal article