We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cutaneous Myeloid Sarcoma: Natural History and Biology of an Uncommon Manifestation of Acute Myeloid Leukemia.
- Authors
HURLEY, M. Yadira; GHAHRAMANI, Grant K.; FRISCH, Stephanie; ARMBRECHT, Eric S.; LIND, Anne C.; NGUYEN, TuDung T.; HASSAN, Anjum; KREISEL, Friederike H.; FRATER, John L.
- Abstract
We conducted a retrospective study of patients with cutaneous myeloid sarcoma, from 2 tertiary care institutions. Eighty-three patients presented, with a mean age of 52 years. Diagnosis of myeloid sarcoma in the skin was difficult due to the low frequency of myeloperoxidase and/or CD34+ cases (56% and 19% of tested cases, respectively). Seventy-one of the 83 patients (86%) had ≥ 1 bone marrow biopsy. Twenty-eight (39%) had acute myeloid leukemia with monocytic differentiation. Twenty-three had other de novo acute myeloid leukemia subtypes. Thirteen patients had other myeloid neoplasms, of which 4 ultimately progressed to an acute myeloid leukemia. Seven had no bone marrow malignancy. Ninety-eight percent of the patients received chemotherapy, and approximately 89% died of causes related to their disease. Cutaneous myeloid sarcoma in most cases represents an aggressive manifestation of acute myeloid leukemia. Diagnosis can be challenging due to lack of myeloblast-associated antigen expression in many cases, and difficulty in distinguishing monocyte-lineage blasts from neoplastic and non-neoplastic mature monocytes.
- Subjects
SARCOMA; MYELOPEROXIDASE; SKIN diseases; MYELOID leukemia; ANTIGENS
- Publication
Acta Dermato-Venereologica, 2013, Vol 93, Issue 3, p319
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-1458