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- Title
Clinical Features and Outcomes of Primary Breast Diffuse Large B-Cell Lymphoma: A Matched-Pair Study.
- Authors
Teng, Ling-Chiao; Liao, Yu-Min; Gau, Jyh-Pyng; Hsiao, Tzu-Hung; Chen, Tsung-Chih; Chen, Mei-Hui; Yeh, Su-Peng; Teng, Chieh-Lin Jerry
- Abstract
Background: The influence of the breast as the primary site on the outcome of diffuse large B-cell lymphoma (DLBCL) and further changes in therapeutic strategies remain unclear. We aimed to compare the outcomes between primary breast and non-breast DLBCL and analyze the genetic profiles of some of the study cohorts using next-generation sequencing. Methods: This matched-pair study reviewed the medical records of 19 patients with stage I and II primary breast DLBCL diagnosed between January 2005 and December 2021 on the basis of the Wiseman and Liao criteria, and we used 1:4 propensity score matching to identify patients with non-breast DLBCL as the control group. The overall response rate, progression-free survival (PFS), and overall survival (OS) were the outcome measures. Results: Patients with primary breast and non-breast DLBCL had a 5-year PFS of 72.6% and 86.9%, respectively (P =.206). These 2 groups also had comparable 5-year OS (86.9% vs 87.8%; P =.772). The breast as the primary site was not associated with inferior PFS (hazard ratio [HR]: 2.14; 95% CI: 0.66-6.96; P =.206) and OS (HR: 1.26; 95% CI: 0.27-5.93; P =.772). Conclusion: Patients with primary breast DLBCL and those with non-breast DLBCL had comparable PFS and OS under rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or R-CHOP-like regimens. Further investigations of the mutation profile, its clinical impact, potential central nervous system relapse, and prognosis of primary breast DLBCL are required.
- Subjects
SEQUENCE analysis; CONFIDENCE intervals; GENETIC mutation; B cell lymphoma; PAIRED comparisons (Mathematics); TREATMENT effectiveness; TUMOR classification; CANCER patients; RESEARCH funding; DESCRIPTIVE statistics; GENOMICS; PROGRESSION-free survival; BREAST tumors; LONGITUDINAL method; OVERALL survival; EVALUATION
- Publication
Clinical Medicine Insights: Oncology, 2023, p1
- ISSN
1179-5549
- Publication type
Article
- DOI
10.1177/11795549231203142