We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Predictors of anti‐VEGF efficacy in chronic central serous chorioretinopathy based on intraocular cytokine levels and pigment epithelium detachment subtypes.
- Authors
Mao, Jianbo; Zhang, Caiyun; Zhang, Shian; Liu, Chenyi; Chen, Nuo; Tao, Jiwei; She, Xiangjun; Zheng, Zicheng; Lv, Zhe; Shen, Lijun
- Abstract
Purpose The aim of this study was to compare intraocular cytokines among different types of pigment epithelial detachments (PEDs) in patients with chronic central serous chorioretinopathy (CSC) and to investigate the association of cytokine levels and PED types with response to anti‐vascular endothelial growth factor (VEGF) therapy. Methods: We included 88 patients with chronic CSC and 30 controls. The anti‐VEGF agent conbercept was given intravitreally to chronic CSC patients. Cytokines VEGF, interleukin‐6 (IL‐6), IL‐8, IL‐10, interferon‐inducible protein‐10 and monocyte chemoattractant protein‐1 in aqueous humour were measured. Treatment efficacy, cytokine levels, changes in best‐corrected visual acuity (BCVA) and optical coherence tomography parameters were assessed at baseline and 1 month after treatment. Results: Patients were divided into three groups: flat irregular PED (FIPED) with choroidal neovascularization (CNV), FIPED without CNV and focal PED. Vascular endothelial growth factor (VEGF) was the only cytokine significantly higher in chronic CSC FIPED patients. There were no significant differences in VEGF between FIPED patients with or without CNV (p = 0.234). At 1 month after conbercept injection, treatment effective rates in FIPED patients with or without CNV were significantly higher than in patients with focal PED (p < 0.05). Best‐corrected visual acuity (BCVA) was improved in both FIPED groups (p < 0.05), but not in the focal PED group (p = 0.180). All three groups had significant decreases in central macular thickness (p < 0.05), and PED heights in FIPED patients were reduced (p < 0.05). Conclusions: Patients with FIPED in chronic CSC had elevated intraocular VEGF levels and responded favourably to conbercept. Anti‐VEGF treatment may be an option for FIPED CSC patients with or without secondary CNV.
- Subjects
VASCULAR endothelial growth factors; ENDOTHELIAL growth factors; AQUEOUS humor; OPTICAL coherence tomography; CYTOKINES
- Publication
Acta Ophthalmologica (1755375X), 2022, Vol 100, Issue 7, pe1385
- ISSN
1755-375X
- Publication type
Article
- DOI
10.1111/aos.15109