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- Title
Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration.
- Authors
Kinnunen, Kati; Petrovski, Goran; Moe, Morten C.; Berta, András; Kaarniranta, Kai
- Abstract
. Age-related macular degeneration (AMD) is attributed to a complex interaction of genetic and environmental factors. It is characterized by degeneration involving the retinal photoreceptors, retinal pigment epithelium (RPE) and Bruch's membrane, as well as alterations in choroidal capillaries. AMD pathogenesis is strongly associated with chronic oxidative stress and inflammation that ultimately lead to protein damage, aggregation and degeneration of RPE. Specific degenerative findings for AMD are accumulation of intracellular lysosomal lipofuscin and extracellular drusens. In this review, we discuss thoroughly RPE-derived mechanisms in AMD pathology.
- Subjects
RETINAL degeneration; AGING; GENETICS; PIGMENT epithelium-derived factor; DEGENERATION (Pathology); DISEASES in older people
- Publication
Acta Ophthalmologica (1755375X), 2012, Vol 90, Issue 4, p299
- ISSN
1755-375X
- Publication type
Article
- DOI
10.1111/j.1755-3768.2011.02179.x