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- Title
Pregnancy Weight Gain Limitation by a Supervised Nutritional Program Influences Placental NF-κB/IKK Complex Expression and Oxidative Stress.
- Authors
Mendieta Zerón, Hugo; Parada Flores, Alejandro; Amaya Chávez, Araceli; Garduño Alanís, Adriana; del Carmen Colín Ferreyra, María; Guadalupe Santillán Benítez, Jonnathan; Saraí Morales Castañeda, Violeta; Victoria Domínguez García, Ma.
- Abstract
Objective: Nuclear factor kappa B (NF-κB) pathway and oxidative stress participate in endothelial dysfunction, which is one of the causes of pre-eclampsia. Among the human antioxidant mechanisms, there are the enzymes catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD). Our aim was to measure NF-κB, its inhibitor (IKK) and oxidative stress in placenta and umbilical cord of pregnant women submitted to a supervised nutritional program. Methods: Two groups were conformed: A) 14 pregnant women with individualized nutritional counseling, and B) 12 pregnant women without nutritional guidance. NF-κB and IKK were assessed by real time PCR (RT-PCR). Enzymatic activity of CAT, GPx, lipoperoxidation (LPO) and SOD were also evaluated. Results: Pregnant women that followed a supervised nutritional program had lower levels of systolic (p=0.03) and diastolic pressure (p=0.043) although they were heavier than the control group (p=0.048). Among all the women, the Spearman correlation was positive between weight gain and placental NF-κB expression (1, p≤0.01). In the placenta, women with nutritional advice had lower enzymatic activity of GPx (p≤0.038) and showed a tendency of IKK to be higher than in women without a nutritional supervised program. Conclusion: A supervised nutritional program in pregnancy offers a proven option to control weight gain, hypertension, NF-κB/IKK complex expression and oxidative stress reactions in the placenta.
- Subjects
MEXICO; BLOOD testing; REGULATION of body weight; CONFIDENCE intervals; NUTRITION counseling; POLYMERASE chain reaction; PREECLAMPSIA; RESEARCH funding; STATISTICS; U-statistics; DATA analysis; OXIDATIVE stress; CONTROL groups; REVERSE transcriptase polymerase chain reaction; PREPROCEDURAL fasting; DATA analysis software; DESCRIPTIVE statistics; PREGNANCY
- Publication
Oman Medical Journal, 2013, Vol 28, Issue 3, p167
- ISSN
1999-768X
- Publication type
Article
- DOI
10.5001/omj.2013.48