We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Orcinol Glucoside Loaded Polymer - Lipid Hybrid Nanostructured Lipid Carriers: Potential Cytotoxic Agents against Gastric, Colon and Hepatoma Carcinoma Cell Lines.
- Authors
Nahak, Prasant; Gajbhiye, Rahul L.; Karmakar, Gourab; Guha, Pritam; Roy, Biplab; Besra, Shila Elizabeth; Bikov, Alexey G.; Akentiev, Alexander V.; Noskov, Boris A.; Nag, Kaushik; Jaisankar, Parasuraman; Panda, Amiya Kumar
- Abstract
Purpose: Orcinol glucoside (OG) - loaded nanostructured lipid carrier (NLC), coated with polyethylene glycol-25/55-stearate (PEG-25/55-SA), were explored for delivering OG to improve in vitro cytotoxicity against gastrointestinal tract (GIT), colon and hepatoma carcinoma cell lines. It is being expected that the PEGylated formulations would possess the sustainability in withstanding the adverse physiological extremities like the most significant metabolic activities and phase I / II enzymatic activities in the intestines.Methods: NLCs were prepared using tristearin, oleic acid and PEG-25/55-stearate by hot homogenization-ultrasonic dispersion; characterized by DLS, TEM, SEM, AFM, entrapment efficiency and drug loading capacity studies.Results: NLC diameter ranged from 160 to 230 nm with negative zeta potential of −8 to −20 mV. TEM/SEM and AFM studies suggest spherical and smooth surface morphologies. Differential scanning calorimetry studies reveal the loss of crystallinity when OG was incorporated into the NLC. NLCs showed initial burst release, followed by sustained release of OG. PEG-NLC exhibited superior anticancer activity against GIT and also in hepatoma cancer cell lines.Conclusions: This is the first report demonstrating a practical approach for possible oral delivery of OG in GIT and targeting hepatoma cancer, warranting further in vivo studies for superior management of GIT cancer.
- Subjects
ANTIBODY-dependent cell cytotoxicity; CELL lines; GLUCOSIDES; GLYCOSIDES; POLYETHYLENE; STEARATES; LYMPHOBLASTOID cell lines; COLON cancer
- Publication
Pharmaceutical Research, 2018, Vol 35, Issue 10, p1
- ISSN
0724-8741
- Publication type
Article
- DOI
10.1007/s11095-018-2469-3