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- Title
Açaí (Euterpe oleracea) pulp-enriched diet induces anxiolytic-like effects and improves memory retention.
- Authors
Silva de Carvalho, Tayana; Brasil, Alódia; Leão, Luana K. R.; Braga, Danielle Valente; Santos-Silva, Mateus; Assad, Nadyme; Luz, Waldo Lucas; de Jesus O. Batista, Evander; de Nazareth Tavares Bastos, Gilmara; Matos Herculano Oliveira, Karen Renata; Wanderley Picanço Diniz, Domingos Luiz; Herculano, Anderson Manoel
- Abstract
Background: Açaí (Euterpe oleracea) has a rich nutritional composition, showing nutraceutical and protective effects in several organs. In this study, the effects of an açaí-enriched diet on motor performance, anxiety-like behavior, and memory retention were deeply investigated. Methods: Eight-week male Wistar rats were fed with an Euterpe oler acea (EO) pulp-enriched diet, an olive oil-enriched (OO) diet (polyunsaturated fatty acid [PUFA] fat control diet), or a chow diet for 31 days (28 days pre-treatment and 3 days during behavioral tests). Afterward, ani mals were submitted to a battery of behavioral tests to evaluate spontaneous motor behavior (open-field test), anxiety-like behavior (elevated plus maze and open-field test), and memory retention (step-down). Oxidative stress in the hippocampus was evaluated by a lipid peroxidation assay. Results: EO-enriched diet did not influence the body weight and food intake but increased the glucose plasmatic level after 31 days under this diet. However, a similar fat-enriched diet stimulated a marked weight gain and reduced the food intake, followed by changes in the plasmatic lipid markers. EO-enriched diet preserved the motor spontaneous performance, increased the exploration in the aversive environment (anxiolytic-like effects), and elevated the latency to step-down (improved memory retention). The EO-enriched diet also reduced the level of lipid peroxidation in the hippo campus. These positive effects of EO-enriched diet can greatly support the usage of this diet as a preventive therapy. Conclusion: Taken together, the current study suggests that Euterpe oleracea-enriched diet promotes anxiolytic- like effects and improves memory consolidation, possibly due to the reduced levels of lipid peroxidation in the hippocampus.
- Subjects
ANXIETY prevention; MEMORY; ANIMAL experimentation; DIET; EUTERPE; RATS; OXIDATIVE stress; RESEARCH funding; PLANT extracts; TRANQUILIZING drugs; LIPID peroxidation (Biology); LIPIDS; PHARMACODYNAMICS
- Publication
Food & Nutrition Research, 2022, Vol 66, Issue 2022, p1
- ISSN
1654-6628
- Publication type
Article
- DOI
10.29219/fnr.v66.8851