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- Title
Mesozeaxanthin protects the liver and reduces cardio-metabolic risk factors in an insulin resistant rodent model.
- Authors
Sahin, Kazim; Orhan, Cemal; Akdemir, Fatih; Tuzcu, Mehmet; Sahin, Nurhan; Yilmaz, Ismet; Ali, Shakir; Deshpande, Jayant; Juturu, Vijaya
- Abstract
Background:Mesozeaxanthin (MZ) is a macular carotenoid which has been reported to have a number of pharmacological properties, including the antioxidant, and anticarcinogenic property, and has been stated to decrease the hepatocyte lipid content. Objective:In this study, we investigated the effect of MZ on cardio-metabolic health risk (CMHR) and its probable mechanisms of action in rats fed a high-fat diet (HFD). Design:Rats were randomly divided into four groups consisting of (i) Control, (ii) MZ, (iii) HFD, and (iv) HFD+MZ. Results:MZ treatment increased the antioxidant enzyme activities and helped improve the liver function. The treatment alleviated CMHR and decreased the level of nuclear factor kappa B (NF-κB p65) and tumor necrosis factor-alpha (TNF-α). The levels of hepatic peroxisome proliferator-activated receptor gamma (PPAR-γ), phosphorylated insulin receptor substrate 1 (p-IRS-1), β,β-carotene 9’,10’-oxygenase 2 (BCO2) and nuclear factor erythroid 2-related factor 2 (Nrf2), which decrease in HFD rats, were found to be significantly higher in MZ supplemented animals. Conclusion:MZ has antioxidant and anti-inflammatory properties and can is reported in this study toprotect against fatty liver and cardio-metabolic syndrome, possibly through regulation of PPAR-γ, IRS-1, Nrf2 and NF-κB proteins, in an insulin-resistant rodent model.
- Subjects
ZEAXANTHIN; ANIMAL experimentation; ANTIOXIDANTS; CARDIOVASCULAR diseases risk factors; CARRIER proteins; FAT content of food; INSULIN resistance; LIVER; PROTEINS; RODENTS; TUMOR necrosis factors; DNA-binding proteins; PEROXISOME proliferator-activated receptors; THERAPEUTICS
- Publication
Food & Nutrition Research, 2017, Vol 61, Issue 1, pN.PAG
- ISSN
1654-6628
- Publication type
Article
- DOI
10.1080/16546628.2017.1353360