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- Title
Stroke and osteoporosis: a Taiwan cohort study.
- Authors
Li Zhang; Zi-Hao Zhang; Qing-Rui Wang; Ying-Ju Su; Ying-Yi Lu; Cong-Liang Zhang; Hung-Pei Tsai; Chieh-Hsin Wu; Zhang, Li; Zhang, Zi-Hao; Wang, Qing-Rui; Su, Ying-Ju; Lu, Ying-Yi; Zhang, Cong-Liang; Tsai, Hung-Pei; Wu, Chieh-Hsin
- Abstract
<bold>Background: </bold>Osteoporosis and stroke are major health problems that have potentially overlapping pathophysiological mechanisms. The aim of this study was to estimate osteoporosis risk in Taiwan patientswho had a stroke.<bold>Method: </bold>This study retrieved data contained in the Taiwan National Health Insurance Research Database for a population-based sample of consecutive patients either hospitalised for stroke or treated for stroke on an outpatient basis. A total of 7550 newly diagnosed patientswho had a stroke were enrolled during 1996-2010. Osteoporosis risk in these patients was then compared with a matched group of patients who had not had a stroke randomly selected from the database at a ratio of 1:4 (n=30 200). The relationship between stroke history and osteoporosis risk was estimated with Cox proportional hazard regression models.<bold>Results: </bold>During the follow-up period, osteoporosis developed in 1537 patients who had a stroke and in 5830 patients who had not had a stroke. The incidence of osteoporosis for cohorts with and without stroke was 32.97 and 14.28 per 1000 person-years, respectively. After controlling for covariates, the overall risk of osteoporosis was 1.82-fold higher in the stroke group than in the non-stroke group. The relative osteoporosis risk contributed by stroke had apparently greater impact among male gender and younger age groups.<bold>Conclusion: </bold>History of stroke is a risk factor for osteoporosis in Taiwan. Much attention to stroke-targeted treatment modalities might minimise adverse outcomes of osteoporosis.
- Subjects
TAIWAN; HIP fractures; OSTEOPOROSIS; STROKE; AGE distribution; CASE-control method; DISEASE incidence; RISK assessment; SEX distribution; LONGITUDINAL method; PROPORTIONAL hazards models
- Publication
Postgraduate Medical Journal, 2021, Vol 97, Issue 1146, p211
- ISSN
0032-5473
- Publication type
journal article
- DOI
10.1136/postgradmedj-2019-136959