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- Title
Thiols and Selenols as Electron-Relay Catalysts for Disulfide-Bond Reduction.
- Authors
Lukesh, John C.; VanVeller, Brett; Raines, Ronald T.
- Abstract
Pass them on! Dithiobutylamine immobilized on a resin is a useful reagent for the reduction of disulfide bonds. Its ability to reduce a disulfide bond in a protein is enhanced greatly if used along with a soluble strained cyclic disulfide or mixed diselenide that relays electrons from the resin to the protein. This electron‐relay catalysis system provides distinct advantages over the use of excess soluble reducing agent alone.
- Subjects
AMINO group; HETEROGENEOUS catalysis; SELENIUM; BIOMIMETIC chemicals; MACROMOLECULES; BIOCONJUGATES
- Publication
Angewandte Chemie International Edition, 2013, Vol 52, Issue 49, p12901
- ISSN
1433-7851
- Publication type
Article
- DOI
10.1002/anie.201307481