We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A Case of Fatal Clostridium perfringens Sepsis with Massive Hemolysis in the Setting of a Coincidental Platelet Transfusion.
- Authors
Boyd, Frank A; O'Leary, Mandy F; Benson, Kaaron; Baluch, Aliyah
- Abstract
A 62-year-old woman with acute myeloid leukemia (AML) died of shock and massive hemolysis shortly after receiving two platelet transfusions at a routine clinic visit. Subsequent investigation into what was initially believed to be an acute hemolytic transfusion reaction secondary to platelet transfusions revealed that the patient died of Clostridium perfringens sepsis leading to massive hemolysis. Further investigation ruled out bacterially-contaminated platelets since a patient blood sample from 2 days prior had Clostridium species. The unusual findings and management considerations for this oncology patient are reviewed and compared with previously reported cases of C. perfringens transfusion-transmitted infections. Oncology patients may be especially susceptible to unusual presentations involving unusual pathogens.
- Subjects
BLOOD; INTENSIVE care units; TACHYPNEA; CELL culture; HEMOLYSIS &; hemolysins; NORADRENALINE; OXYGEN saturation; CLOSTRIDIUM diseases; SEPSIS; BLOOD platelet transfusion; CYANOSIS; HEMATOPOIETIC stem cell transplantation; HYPOXEMIA; HYDROCORTISONE
- Publication
Laboratory Medicine, 2023, Vol 54, Issue 4, pe108
- ISSN
0007-5027
- Publication type
Article
- DOI
10.1093/labmed/lmac135