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- Title
Roux-en-Y Bypass Gastroplasty: Markers of Oxidative Stress 6 Months After Surgery.
- Authors
Boesing, Fernanda; Moreira, Emilia Addison Machado; Wilhelm-Filho, Danilo; Vigil, Silvana Virgínia Gagliotti; Parizottto, Eduardo Bennedetti; Inácio, Déborah Bunn; Portari, Guilherme Vannucchi; Trindade, Erasmo Benício Santos Moraes; Jordão-Júnior, Alceu Afonso; Fröde, Tânia Silvia
- Abstract
Background: This study examined the effect of weight loss on energy intake, vitamin C, E, β-carotene (diet/blood), reduced glutathione (GSH), C-reactive protein (CRP), thiobarbituric acid reactive substances (TBARS), catalase, and myeloperoxidase, in patients with Roux-en-Y bypass gastroplasty. Methods: Prospective clinical study with control (C) and bariatric (B) groups ( n = 20 each). Age was 38.8 ± 11.1 (C) and 37.8 ± 11.2 years (B), and body mass indices (BMI) were 22.4 ± 2.4 and 48.1 ± 8.7 kg/m, respectively. Group C was assessed on a single occasion and B at three time points (basal period and 3 and 6 months after gastroplasty). Results: BMI was decreased at three (38.3 ± 1.7, P = 0.018) and 6 months after surgery (34.9 ± 1.7, P < 0.001). Mean weight loss was 20.53 ± 1.1 after three and 27.96 ± 1.3 kg after 6 months. Serum vitamin C and β-carotene ( P < 0.01 and P < 0.001, respectively) were increased at 6 months compared to basal. Basal serum vitamin C ( P = 0.001) and β-carotene ( P < 0.001) were lower compared to controls. Serum vitamin E corrected for cholesterol and triglycerides was higher in group B at three ( P = 0.01) and 6 months ( P = 0.001) and lower at basal ( P < 0.001) compared to controls. GSH was higher in controls ( P < 0.001) compared to basal. Catalase ( P = 0.01) and TBARS ( P < 0.001) were higher in group B at 6 months. TBARS were higher ( P < 0.001) at basal compared to controls. Myeloperoxidase and CRP decreased in group B after three ( P = 0.028, P = 0.010) and 6 months ( P < 0.001, P = 0.001), respectively. Conclusions: Roux-en-Y bypass gastroplasty led to decreased proinflammatory parameters together with increased nutritional antioxidants, catalase, and TBARS, and decreased GSH 6 months after surgery.
- Subjects
BARIATRIC surgery; OXIDATIVE stress; INFLAMMATORY mediators; VITAMIN C; CAROTENES; GLUTATHIONE; CATALASE; GASTRIC bypass
- Publication
Obesity Surgery, 2010, Vol 20, Issue 9, p1236
- ISSN
0960-8923
- Publication type
Article
- DOI
10.1007/s11695-010-0196-x