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- Title
The effects of fluoride and mineralising treatments on plaque microcosm Ca, P and F, pH responses and cariogenicity.
- Authors
Anoker, Linny; Swain, Michael V.; Wong, Lisa; Sissons, Chris
- Abstract
Objective: To investigate the effects of fluoride (F), calcium-phosphate-monofluorophosphate-urea (CPMU) mineralising solution, and casein on plaque pH and calcium (Ca), phosphate (P) and F content, and the ability of plaque to induce carious lesions in enamel. Methods: Plaque microcosms were cultured in cariogenic growth conditions on enamel specimens for 28d in a "multiplaque artificial mouth". The plaques were supplied 5 times daily with 10% sucrose (l.5m1 over 6 mm) over a 12h period followed by a 12h rest period. Duplicate plaques were pulsed with 0, 1000, 3000 and 5000ppm F (1.5m1 over 6mm) or 2% w/v casein (l.25m1 over 30mm) twice daily. One of each pair was also pulsed with CPMU (1.5m1 over 6mm). Plaque pH was monitored during growth. After 28 days' culture, plaque Ca, P and F levels were quantified and lesion depth in enamel was measured by backscattered electron SEM. Results: F pulses raised the plaque pH, which was otherwise below 4 during sucrose pulsing, while CPMU hastened and raised the recovery pH. Plaque Ca, P and F levels substantially increased with increasing concentrations of applied F, particularly in the presence of CPMU (P<0.0l). In the absence of either F or CPMU, enamel lesions were formed with extensive enamel loss. Conclusions: CPMU and F supplied to plaque microcosms substantially reduce plaque cariogenicity to enamel under highly cariogenic experimental conditions. This was associated with an increase in plaque pH, plaque F and Ca levels.
- Subjects
FLUORIDES; DENTAL plaque; DENTAL enamel; CALCIUM phosphate; SUCROSE; THERAPEUTICS
- Publication
New Zealand Dental Journal, 2011, Vol 107, Issue 1, p12
- ISSN
0028-8047
- Publication type
Article