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- Title
Continuous infusion vincristine and bleomycin with high dose methotrexate for resistant non-Hodgkin's lymphoma.
- Authors
Hollister, Dickerman; Silver, Richard T.; Gordon, Bruce; Coleman, Morton; Hollister, D Jr; Silver, R T; Gordon, B; Coleman, M
- Abstract
Sixteen patients with resistant non-Hodgkin's lymphoma were treated with continuous infusions of vincristine (1-2 mg/m2 daily X 2 days) and bleomycin (0.25 mg/kg bolus dose, then 0.25 mg/kg/daily X 5 days). Responding patients received high dose methotrexate (1500 mg/m2) with citrovorum rescue on days 15, 22, 29, 36. Treatment cycles were repeated every six weeks in responding patients. The response frequency was 50% (three complete and five partial responses). Median response duration was 29 weeks. Major toxicity included stomatitis (63%) and leukopenia (44%). One episode each of possible hypersensitivity pneumonitis and paralytic ileus occurred. Continuous infusions of vincristine and bleomycin should be studied further in less critically ill patients.
- Publication
Cancer (0008543X), 1982, Vol 50, Issue 9, p1690
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/1097-0142(19821101)50:9<1690::AID-CNCR2820500906>3.0.CO;2-Z