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- Title
Immunophenotyping of Compound and Spitz Nevi and Vertical Growth-Phase Melanomas Using a Panel of Monoclonal Antibodies Reactive in Parrafin Sections.
- Authors
Lazzaro, Bette; Elder, David E.; Rebers, Ahlke; Power, Laurie; Herlyn, Meenhard; Menrad, Andreas; Johnson, Bernett
- Abstract
The article focuses on immunophenotyping of compound and Spitz nevi and vertical growth-phase melanomas using a panel of monoclonal antibodies reactive in paraffin sections. Spitz nevus, also called spindle and epitheltoid cell nevus or juvenile melanoma, is a benign neoplasm of epidermal melanocytes. Its histologic appearance is occasionally difficult to distinguish from that of tumorigenic malignant melanoma of the nodular type. Cells of a Spitz nevus are both spindled and epitheliod in form and characteristically migrate from the epidermis in an invasive pattern that often extends deep into the dermis.
- Subjects
NEVUS; MELANOMA; IMMUNOPHENOTYPING; MONOCLONAL antibodies; EPIDERMIS; DERMIS; TUMORS
- Publication
Journal of Investigative Dermatology, 1993, Vol 100, Issue 3, p313S
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1038/jid.1993.54