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- Title
Phosphoinositide-Mediated Signal Transduction in Normal and Psoriatic Epidermis.
- Authors
Fisher, Gary J.; Talwar, Harvinder S.; Tavakkol, Amir; Esmann, Jorgen; Baldassare, Joseph J.; Elder, James T.; Griffiths, Christopher E. M.; Baadsgaard, Ole; Cooper, Kevin D.; Voorhees, John J.
- Abstract
The article focuses on phosphoinositide-mediated signal transduction in normal and psoriatic epidermis. Psoriasis is characterized by cutaneous inflammation and misregulation of epidermal cell homeostasis. The phospholipase C/protein kinase C (PLC/PKC) signal-transduction system participates in the activation of a wide variety of cell types and is inextricably linked to fundamental biologic processes such as immunity, inflammation, differentiation and proliferation. The PLC/PKC signal-transduction system participates in the regulation of all major cell types in skin, including keratinocytes, melanocytes, Langerhans cells, endothelial cells and fibroblasts.
- Subjects
PSORIASIS; EPIDERMIS; PHOSPHOINOSITIDES; PHOSPHOLIPASE C; PROTEIN kinase C; HOMEOSTASIS
- Publication
Journal of Investigative Dermatology, 1990, Vol 95, Issue 5, p15S
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12505672