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- Title
Ro(SS-A) Positive Sjogren's/Lupus Erythematosus (SC/LE) Overlap Patients Are Associated with the HLA-DR3 and/or DRw6 Phenotypes.
- Authors
Provost, Thomas T.; Talal, Norman; Bias, Wilma; Harley, John B.; Reichlin, Morris; Alexander, Elaine L.
- Abstract
Ro(SS-A) positive female Sjögren's syndrome (SS) lupus erythematosus (LE) overlap patients are a clinically and serologically homogeneous group generally demonstrating prominent subacute cutaneous lupus erythematosus (SCLE) lesions, cutaneous vasculitis, peripheral and central nervous sytem disease, pulmonary disease, and a low frequency of glomerulonephritis. They commonly demonstrate rheumatoid factor, hypergammaglobulinemia, antinuclear and Ro(SS-A) La(SS-B) antibody activity. This study indicates that these patients are also immunogenetically similar, sharing a statistically significant increased frequency of HLA-B8, DR3, DRW6, DQ2, and DRw52. Sixty-three percent of these SS/LE patients possess the extended haplotype (P-value 6.0 × 10-3; RR 9.5) HLA-B8, DR3, DQ2, DRw52. One hundred percent of this SS/LE cohort was DR3 or DRw6 (P-value ⩽ 5.0 × 10-3; relative risk 19.1). Fifty percent of these patients were HLA DR3/DRw6 heterozygotes (P-value 1.5 × 10-3;, relative risk 31.2). Thus, HLA-DR3 and DRw6 (Ro(SS-A) positive SS/LE patients may possess a similar, if not unique, DR region DNA nucleotide sequence involved in disease susceptibility or immune regulation.
- Subjects
SJOGREN'S syndrome; LUPUS erythematosus; LUNG diseases; GLOMERULONEPHRITIS; HYPERGAMMAGLOBULINEMIA
- Publication
Journal of Investigative Dermatology, 1988, Vol 91, Issue 4, p369
- ISSN
0022-202X
- Publication type
Article
- DOI
10.1111/1523-1747.ep12476204