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- Title
Red cell transfusions: Is less always best?: How confident are we that restrictive transfusion strategies should be the standard of care default transfusion practice?
- Authors
Mo, Allison; Stanworth, Simon J.; Shortt, Jake; Wood, Erica M.; McQuilten, Zoe K.
- Abstract
Despite their high transfusion requirements, few trials have investigated restrictive versus liberal transfusion thresholds in patients undergoing intensive chemotherapy/radiotherapy or hematopoietic stem cell transplantation (HSCT), as highlighted by a 2017 Cochrane review, which identified only four studies involving such patients (240 patients). The recently published Red Cell Transfusion in Myelodysplastic Syndromes (REDDS) study39 demonstrated feasibility of randomizing and maintaining blinding of 38 transfusion-dependent MDS patients randomized to a restrictive versus liberal transfusion threshold. : How confident are we that restrictive transfusion strategies should be the standard of care default transfusion practice? Ultimately, true PBM is not simply about numbers of units of blood used, but must also focus directly on the patient, and includes patient QoL and function, and patient preferences, to optimize their transfusion management and allow best use of this precious community resource.
- Subjects
BLOOD transfusion reaction; GASTROINTESTINAL hemorrhage; ERYTHROCYTES; CLINICAL trials monitoring; DEFAULT (Finance); RED blood cell transfusion; VON Willebrand disease
- Publication
Transfusion, 2021, Vol 61, Issue 7, p2195
- ISSN
0041-1132
- Publication type
Article
- DOI
10.1111/trf.16429