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- Title
Photoinduced Nitric Oxide and Singlet Oxygen Release from ZnPC Liposome Vehicle Associated with the Nitrosyl Ruthenium Complex: Synergistic Effects in Photodynamic Therapy Application.
- Authors
Maranho, Daniela Silva; de Lima, Renata Galvão; Primo, Fernando Lucas; da Silva, Roberto Santana; Tedesco, Antonio Claudio
- Abstract
Under continuous photolysis at 675 nm, liposomal zinc phthalocyanine associated with nitrosyl ruthenium complex [Ru(NH.NHq)(tpy)NO]3+ showed the detection and quantification of nitric oxide (NO) and singlet oxygen (1O2) release. Photophysical and photochemical results demonstrated that the interaction between the nitrosyl ruthenium complex and the photosensitizer can enable an electron transfer process from the photosensitizer to the nitrosyl ruthenium complex which leads to NO release. Synergistic action of both photosensitizers and the nitrosyl ruthenium complex results in the production of reactive oxygen species and reactive nitrogen species, which is a potent oxidizing agent to many biological tissues, in particular neoplastic cells.
- Subjects
NITRIC oxide; REACTIVE oxygen species; LIPOSOMES; NITROGEN oxychlorides; PHOTOCHEMOTHERAPY; PHOTOCHEMISTRY
- Publication
Photochemistry & Photobiology, 2009, Vol 85, Issue 3, p705
- ISSN
0031-8655
- Publication type
Article
- DOI
10.1111/j.1751-1097.2008.00481.x