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- Title
Mechanism of albuminuria associated with cardiovascular disease and kidney disease.
- Authors
Russo, Leileata M.; Comper, Wayne D.; Osick, Tanya M.
- Abstract
Mechanism of albuminuria associated with cardiovascular disease and kidney disease. The major underlying factors associated with tissue damage and fibrosis in cardiovascular and kidney disease are the up-regulation and action of growth factors such as transforming growth factor-beta (TGF-β) and cytokines produced in response to changes in systemic factors, particularly blood pressure or hyperglycemia. This study identifies the relationship of elevated levels of TGF-β to increased levels of intact albumin in the urine (micro- and macroalbuminuria). This mechanism may be directly linked to the effect of TGF-β on albumin uptake and the lysosomal breakdown of filtered albumin by proximal tubular cells prior to excretion.
- Subjects
ALBUMINURIA; KIDNEY diseases; CARDIOVASCULAR diseases; GROWTH factors; CYTOKINES
- Publication
Kidney International Supplement, 2004, Issue 92, pS67
- ISSN
0098-6577
- Publication type
Article
- DOI
10.1111/j.1523-1755.2004.09218.x