We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A probable case of syndrome of inappropriate antidiuretic hormone secretion associated with linezolid.
- Authors
SEUNG HEE BAIK; YOON KYUNG CHOI; HYUN SEO KIM; YOUNG KYUNG YOON; JANG WOOK SOHN; MIN JA KIM
- Abstract
Purpose. A probable case of syndrome of inappropriate antidiuretic hormone secretion (SIADH) due to linezolid use is reported. Summary. An 81-year-old Korean woman hospitalized for progressive malignant otitis externa due to methicillin-resistant Staphylococcus aureus infection was started on linezolid therapy (600 mg i.v. twice daily). On day 22 of linezolid use, the patient had severe hyponatremia (serum sodium concentration, 118 meq/L), with stable vital signs and no specific physical findings except for somnolence. The patient's urine sodium concentration was 1183 meq/L, and her serum and urine osmolarity values were 250 and 357 mOsm/kg, respectively; these findings were consistent with SIADH. Hypertonic saline infusion and fluid restriction (<1 L/day) were continued for four days with the aim of achieving a desired serum sodium concentration of 130 meq/L. On day 26 of linezolid therapy, the drug was discontinued due to development of progressive anemia (hemoglobin concentration, 6.7 g/dL). The next day, the patient's serum sodium concentration increased abruptly to 135 meq/L and remained stable until hospital discharge. After multiple alternative etiologies were excluded, drug-induced SIADH due to linezolid use was determined to be the most likely diagnosis. Using the adverse drug reaction probability scale of Naranjo et al., the case was assigned a score of 6, indicating a probable association between linezolid use and SIADH. Conclusion. SIADH was observed in a woman who was administered linezolid for more than three weeks, with concurrent development of progressive severe anemia associated with linezolid toxicity. The patient's hyponatremia resolved after cessation of linezolid use.
- Subjects
ANEMIA diagnosis; FLUID therapy; HYPONATREMIA; OTITIS externa; SODIUM; METHICILLIN-resistant staphylococcus aureus; LINEZOLID; HYPERTONIC saline solutions; INAPPROPRIATE ADH syndrome; DIAGNOSIS; THERAPEUTICS
- Publication
American Journal of Health-System Pharmacy, 2015, Vol 72, Issue 21, p1865
- ISSN
1079-2082
- Publication type
Article
- DOI
10.2146/ajhp150208