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- Title
Genome-wide association study identifies two susceptibility loci for osteosarcoma.
- Authors
Savage, Sharon A; Mirabello, Lisa; Wang, Zhaoming; Gastier-Foster, Julie M; Gorlick, Richard; Khanna, Chand; Flanagan, Adrienne M; Tirabosco, Roberto; Andrulis, Irene L; Wunder, Jay S; Gokgoz, Nalan; Patiño-Garcia, Ana; Sierrasesúmaga, Luis; Lecanda, Fernando; Kurucu, Nilgün; Ilhan, Inci Ergurhan; Sari, Neriman; Serra, Massimo; Hattinger, Claudia; Picci, Piero
- Abstract
Osteosarcoma is the most common primary bone malignancy of adolescents and young adults. To better understand the genetic etiology of osteosarcoma, we performed a multistage genome-wide association study consisting of 941 individuals with osteosarcoma (cases) and 3,291 cancer-free adult controls of European ancestry. Two loci achieved genome-wide significance: a locus in the GRM4 gene at 6p21.3 (encoding glutamate receptor metabotropic 4; rs1906953; P = 8.1 × 10−9) and a locus in the gene desert at 2p25.2 (rs7591996 and rs10208273; P = 1.0 × 10−8 and 2.9 × 10−7, respectively). These two loci warrant further exploration to uncover the biological mechanisms underlying susceptibility to osteosarcoma.
- Subjects
OSTEOSARCOMA; CANCER susceptibility; GENOMES; LOCUS (Genetics); DISEASES in teenagers; CANCER genetics; ETIOLOGY of cancer
- Publication
Nature Genetics, 2013, Vol 45, Issue 7, p799
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng.2645