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- Title
A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities.
- Authors
Kochi, Yuta; Yamada, Ryo; Suzuki, Akari; Harley, John B; Shirasawa, Senji; Sawada, Tetsuji; Bae, Sang-Cheol; Tokuhiro, Shinya; Chang, Xiaotian; Sekine, Akihiro; Takahashi, Atsushi; Tsunoda, Tatsuhiko; Ohnishi, Yozo; Kaufman, Kenneth M; Kang, Changsoo Paul; Kang, Changwon; Otsubo, Shigeru; Yumura, Wako; Mimori, Akio; Koike, Takao
- Abstract
Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology. Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085). This polymorphism alters the binding affinity of nuclear factor-?B and regulates FCRL3 expression. We observed high FCRL3 expression on B cells and augmented autoantibody production in individuals with the disease-susceptible genotype. We also found associations between the SNP and susceptibility to autoimmune thyroid disease and systemic lupus erythematosus. FCRL3 may therefore have a pivotal role in autoimmunity.
- Subjects
RHEUMATOID arthritis; AUTOANTIBODIES; ETIOLOGY of diseases; GENETIC polymorphisms; B cells; GENOMES
- Publication
Nature Genetics, 2005, Vol 37, Issue 5, p478
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/ng1540