We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma.
- Authors
Bernstein, Jonathan M.; Andrews, Timothy D.; Slevin, Nick J.; West, Catharine M. L.; Homer, Jarrod J.
- Abstract
Objectives/Hypothesis To determine the prognostic value of hypoxia-associated markers carbonic anhydrase-9 (CA-9) and hypoxia-inducible factor-1α (HIF-1α) in advanced larynx and hypopharynx squamous cell carcinoma (SCCa) treated by organ preservation strategies. Study Design Retrospective cohort study. Methods Pretreatment CA-9 and HIF-1α expression, clinicopathologic data, and tumor volume were analyzed in a series of 114 patients with T3-4 SCCa larynx or hypopharynx treated by (chemo)radiation. Results Adverse prognostic factors for locoregional control were T4 classification ( P = 0.008), and for disease-specific survival were CA-9 positivity ( P = 0.039), T4 classification ( P = 0.001), larger tumor volume ( P = 0.004), N1-3 classification ( P = 0.002), and pretreatment hemoglobin < 13.0 g/dl ( P = 0.014). With increasing CA-9 expression, there was a trend to increasing tumor recurrence (Ptrend = 0.009) and decreasing survival (Ptrend = 0.002). On multivariate analysis, independent variables were T4 classification (hazard ratio [HR] 13.54, P = 0.01) for locoregional failure, and CA-9 positivity (HR = 8.02, P = 0.042) and higher tumor volume (HR = 3.33, P = 0.007) for disease-specific mortality. Conclusion This is the first study to look specifically at T3 and T4 SCCa larynx and hypopharynx for a relationship between hypoxia-associated marker expression and clinical outcome. Pretreatment immunohistochemical CA-9 expression is an adverse prognostic factor for disease-specific survival, indicating that CA-9 expression may confer a more aggressive tumor phenotype. Level of Evidence 4. Laryngoscope, 125:E8-E15, 2015
- Subjects
CANCER treatment; SQUAMOUS cell carcinoma; HYPOXEMIA; HYPOPHARYNGEAL cancer; MULTIVARIATE analysis; HEMOGLOBINS; THERAPEUTICS
- Publication
Laryngoscope, 2015, Vol 125, Issue 1, pE8
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1002/lary.24933