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- Title
Collagen Fiber and Versican Distribution Within the Lamina Propria of Fetal Vocal Folds.
- Authors
Buhler, Rogerio Borghi; Sennes, Luiz U.; Mauad, Thais; Melo, Erich Christiano M.; Silva, Luiz Fernando F.; Saldiva, Paulo Hilário N.
- Abstract
Objectives: To analyze the presence and distribution of collagen fibers and versican in human vocal fold lamina propria of fetal larynges. Study Design: Cross sectional analysis of cadaveric vocal folds of human fetuses. Methods: Seven fetal larynges obtained from 28- to 36-week-old fetuses were analyzed with the Picrosirius-polarization method, immunohistochemistry, and image analysis. Results: Collagen fibers within the lamina propria exhibited a monolaminar distribution pattern and spatial arrangement in 'wicker basket.' Versican distribution was larger in the superficial and intermediate layers when compared to the deep layer. Conclusion: Our findings suggest that collagen and versican distribution and arrangement within the lamina propria in the developing fetus are important for vocalization at birth.
- Publication
Laryngoscope, 2008, Vol 118, Issue 2, p371
- ISSN
0023-852X
- Publication type
Article
- DOI
10.1097/MLG.0b013e318159aa0d