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- Title
Stability of vancomycin hydrochloride employed in antimicrobial seal solutions of central intravenous catheters.
- Authors
Barros, Daniele Porto; de Carvalho Onofre, Priscilla Sete; Affonso Fonseca, Fernando Luiz; Pires Rosa, Paulo César; da Luz Gonçalves Pedreira, Mavilde; Sorgini Peterlini, Maria Angélica
- Abstract
Objective: to verify the stability of vancomycin hydrochloride in antimicrobial seal solutions with and without association of heparin sodium according to temperature and association time. Method: an experimental study designed for the analysis of hydrogenionic potential and concentration by means of high-efficiency liquid chromatography of vancomycin hydrochloride (n=06) and vancomycin hydrochloride and heparin sodium (n=06). The solutions studied were submitted to absence of light, as well as to 22°C and 37°C. Analyses in triplicate (n=192) were performed at the initial moment (T0) and three (T3), eight (T8) and 24 hours (T24) after preparation. The data were submitted to analysis of variance (p≤0.05). Results: concentration of the antimicrobial at 22°C presented a reduction (T0-T8) and a subsequent increase (T24); hydrogenionic potential decreased significantly over time. At 37°C, the concentration increased up to T3 and decreased at T24, with a reduction of hydrogenionic potential up to 24 hours. Concentration of the vancomycin hydrochloride and heparin sodium solutions varied with a reduction at 22°C, accompanied by increased hydrogenionic potential. Precipitate formation was observed by visual inspection of the vancomycin hydrochloride-heparin sodium association (T3). Conclusion: pharmacological stability of vancomycin hydrochloride (5 mg/mL) and physical incompatibility with heparin sodium (100 IU/mL) were evidenced after three hours of association in the antimicrobial seal solutions studied.
- Subjects
BRAZIL; EXPERIMENTAL design; CATHETER-related infections; TEMPERATURE; HIGH performance liquid chromatography; INTRAVENOUS therapy; PHARMACOLOGY; VANCOMYCIN; LABORATORIES; MEDICAL protocols; DRUG stability; DRUG interactions; DESCRIPTIVE statistics; SOLUTION (Chemistry); HEPARIN; CENTRAL venous catheters; MICROBIAL contamination; DOSAGE forms of drugs
- Publication
Revista Latino-Americana de Enfermagem (RLAE), 2022, Vol 30, p1
- ISSN
1518-8345
- Publication type
Article
- DOI
10.1590/1518.8345.5869.3621