We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of voluntary running wheel exercise on the growth and metastasis of transplanted prostate cancer in rates.
- Authors
Bryner, R.; Riggs, D.; Donley, D.; White, J.; Ullrich, I.; Lamm, D.; Yeater, R.
- Abstract
Regular physical activity has been associated with a decreased incidence of certain cancers. Some, animal studies have found that exercise training enhances resistance to experimentally induced tumor growth, but prostate cancer has received little attention. This study examined the effects of voluntary wheel running on the growth and metastasis of transplanted prostate cancer in rats. Animals were randomly assigned to running wheel (RW: n = 19) or control (C: n = 18) groups. The RW animals had free access to the running wheels throughout the study except for week 12. Animals were given a maximal treadmill test before training and during week 12 (baseline). Forty-eight hours after the treadmill test, all animals were inoculated with 1 x 106 transplantable rat prostate cancer subcutaneously (day = 0). Tumor incidence and volume were determined biweekly until sacrifice at day 52. Weight and peak VO2 did not differ between groups before training. Weight tended to be greater (p =. 029) for C vs RW (C: 417.1 ± 51.5 vs. RW: 377.2 ± 36.1 grams) and peak VO2 greater (p < 0.01) for RW vs C (RW: 67.0 ± 4.8 vs. C: 56.4 ± 3.3 ml/kg/min) at week 12. Mean tumor volume across all measurements was lower (p <0.01) in RW vs C (6668.2 ± 5678.0 vs 7942.0 ± 7020.7 mm³). Number of lung metastatic lesions did not differ between groups (RW: 214.5 ± 120.6 vs C: 181.6 ± 137.7). Tumor volume correlated negatively (p = .05) with the 12-week max treadmill time. In conclusion, voluntary wheel running produced a significant improvement in the cardiorespiratory fitness of rats and was associated with a significant reduction in prostate tumor volume. However, exercise had no effect on lung metastases.
- Subjects
PHYSICAL fitness; CANCER; EXERCISE; TUMOR growth; PROSTATE cancer; LABORATORY animals
- Publication
Journal of Exercise Physiology Online, 1998, p1
- ISSN
1097-9751
- Publication type
Article