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- Title
A rat model of dilated cardiomyopathy to investigate partial left ventriculectomy.
- Authors
Yuasa, Sadatoshi; Nishina, Takeshi; Nishimura, Kazunobu; Miwa, Senri; Ikeda, Tadashi; Hanyu, Michiya; Fujioka, Yasutada; Kihara, Yasuki; Sasayama, Sigetake; Komeda, Masashi; Yuasa, S; Nishina, T; Nishimura, K; Miwa, S; Ikeda, T; Hanyu, M; Fujioka, Y; Kihara, Y; Sasayama, S; Komeda, M
- Abstract
<bold>Background: </bold>This study is the first to assess a small animal model of dilated cardiomyopathy (DCM) for evaluation of partial left ventriculectomy.<bold>Method: </bold>Eighteen Dahl salt-sensitive (DS) rats were divided into three groups. Six rats were fed an 8% high-salt diet from the age of 7 weeks (Group 1), and similarly six rats from 8 weeks (Group 2) and six from 9 weeks (Group 3). Blood pressure (BP) was measured by the tail-cuff method and left ventricular (LV) dimensions by echocardiography.<bold>Results: </bold>In Groups 1 and 2, systolic BP rose and reached 200 mmHg by the 10th to 11th week, when all rats died within a week without signs of heart failure. However, in Group 3, systolic BP gradually rose to 196+/-15 mmHg (mean +/- SD) at the age of 14 weeks, when LV end-diastolic diameter (EDD) was 6.2+/-0.4 mm (control 5.1+/-0.7 mm) and LV fractional shortening (FS) was 77+/-3% (control 68+/-3%). At the age of 25 to 30 weeks, all rats in Group 3 showed signs of congestive heart failure, systolic BP remained high, EDD markedly increased (8.7+/-0.6 mm), and LVFS decreased (38.9+/-8.1%). From this stage, rats survived for 13.7+/-5.9 days. We employed the Group 3 model for our pilot PLV study. Eight rats had PLV with a beating heart by plicating the LV area between the papillary muscle bases. Two rats died perioperatively but the rest survived (60% survival 3 weeks after PLV). Postoperatively, the rats' LVEDD decreased and FS improved significantly.<bold>Conclusions: </bold>Using DS rats, we developed a DCM model for investigating PLV. The model may contribute to scientific investigation of PLV.
- Publication
Journal of Cardiac Surgery, 2001, Vol 16, Issue 1, p40
- ISSN
0886-0440
- Publication type
journal article
- DOI
10.1111/j.1540-8191.2001.tb00482.x