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- Title
(−)-Guaiol triggers immunogenic cell death and inhibits tumor growth in non-small cell lung cancer.
- Authors
Yang, Xiaohui; Yang, Junling; Gu, Xiaoxia; Tao, Yuhua; Ji, Hongjuan; Miao, Xian; Shen, Shuijie; Zang, Haiyang
- Abstract
(−)-Guaiol is a sesquiterpenoid found in many traditional Chinese medicines with potent antitumor activity. However, its therapeutic effect and mechanism in non-small cell lung cancer (NSCLC) have not been fully elucidated. In this study, (−)-Guaiol was found to induce immunogenic cell death (ICD) in NSCLC in vitro. Using (−)-Guaiol in vivo, we found that (−)-Guaiol could suppress tumor growth, increase dendritic cell activation, and enhance T-cell infiltration. Vaccination experiments suggest that cellular immunoprophylaxis after (−)-Guaiol intervention can suppress tumor growth. Previous studies have found that (−)-Guaiol induces apoptosis and autophagy in NSCLC. Apoptosis and autophagy are closely related to ICD. To explore whether autophagy and apoptosis are involved in (−)-Guaiol-induced ICD, we used inhibitors of apoptosis and autophagy. The results showed that the release of damage-associated molecular patterns (DAMPs) was partly reversed after inhibition of apoptosis and autophagy. In conclusion, these results suggested that the (−)-Guaiol triggers immunogenic cell death and inhibits tumor growth in NSCLC.
- Subjects
NON-small-cell lung carcinoma; CELL death; TUMOR growth; APOPTOSIS inhibition; CELL growth; CHINESE medicine
- Publication
Molecular & Cellular Biochemistry, 2023, Vol 478, Issue 7, p1611
- ISSN
0300-8177
- Publication type
Article
- DOI
10.1007/s11010-022-04613-y