We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bacterial and inflammatory behavior of implants in the early healing phase of chronic periodontitis.
- Authors
Cosgarea, Raluca; Dannewitz, Bettina; Sculean, Anton; Bran, Simion; Baciut, Grigore; Eick, Sigrun
- Abstract
Objective: To assess the pattern of early bacterial colonization at implants and teeth in patients with a history of chronic periodontitis compared with a group of healthy subjects. Furthermore, the presence of host-derived markers at teeth and implants in the two subject groups was determined. Method and Materials: Subgingival and submucosal plaque and gingival crevicular fluid samples from 37 nonsubmerged healing dental implants and the deepest tooth sites per quadrant were analyzed 2 to 5 months after implant insertion. The presence of periodontal pathogens was assessed by means of real-time polymerase chain reaction. Further, the levels of interleukin (IL)-1β, IL-8, and IL-10; secretory leukocyte protease inhibitor; and the neutrophil elastase activity were determined. Results: Eleven patients with chronic periodontitis and 13 subjects without periodontitis were recruited the teeth and implants. The presence was always higher in the chronic periodontitis group; the difference was significant for Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans at both the implants and teeth. The levels of IL-1β were higher at teeth than at implants; in contrast, more IL-10 was measured at the implants. Conclusion: The present results indicate that (1) dental implants inserted in periodontally compromised patients are colonized with periodontal pathogens within the first weeks of healing; (2) inflammatory markers (IL-1β) are present in higher levels at teeth as compared with implants, whereas at implants, anti-inflammatory cytokines (IL-10) might play the important role; and (3) the importance of periodontal treatment prior to implant insertion to reduce bacterial load and inflammation should be emphasized.
- Subjects
ACADEMIC medical centers; BIOMARKERS; CHI-squared test; ENZYME-linked immunosorbent assay; INFLAMMATION; MICROBIAL sensitivity tests; PERIODONTITIS; PANORAMIC radiography; STATISTICS; U-statistics; DATA analysis; EQUIPMENT &; supplies; DATA analysis software; DESCRIPTIVE statistics
- Publication
Quintessence International, 2012, Vol 43, Issue 6, p491
- ISSN
0033-6572
- Publication type
Article