We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
pH‐Sensitive Poly(ethylene glycol)/Poly(ethoxyethyl glycidyl ether) Block Copolymers: Synthesis, Characterization, Encapsulation, and Delivery of a Hydrophobic Drug.
- Authors
Illy, Nicolas; Corcé, Vincent; Zimbron, Jérémy; Molinié, Vincent; Labourel, Mélanie; Tresset, Guillaume; Degrouard, Jéril; Salmain, Michèle; Guégan, Philippe
- Abstract
Curcumin is a natural polyphenolic compound known for its numerous pharmacological properties. However, its low water solubility and instability at neutral pH are serious drawbacks preventing its use as an oral drug. Well‐defined amphiphilic poly(ethylene glycol)‐block‐poly(ethoxyethyl glycidyl ether) (PEG‐b‐PEEGE) block copolymers carrying acid‐labile acetal groups are synthesized by anionic ring‐opening polymerization and investigated as potential pH‐sensitive nano‐carriers for delivery of curcumin to cancer cells. The nanoparticles, resulting from copolymer self‐assembly in aqueous media, are characterized by dynamic light scattering and cryo‐transmission electron microscopy. The nanoparticles' stabilities are evaluated in three different phosphate buffers (pH = 7.2, 6.4, and 5.3). The stability decreases at lower pH and a complete disappearance of the nanoparticles is noticed after 4 days at pH 5.3. Curcumin is encapsulated in hydrophobic core of mPEG40‐b‐PEEGE25 nanoparticles allowing significant enhancements of curcumin solubility in water and lifetime at neutral pH. In vitro curcumin release is studied at different pH by UV‐spectroscopy and high‐performance liquid chromatography (HPLC). The cytotoxicity of curcumin and curcumin encapsulated in micelles is evaluated by cell viability 3‐(4,5‐Dimethyl‐2‐thiazolyl)‐2,5‐diphenyl‐2H‐tetrazolium bromide (MTT) assay on MDA‐MB‐231 human breast cancer cells.
- Subjects
COPOLYMERIZATION; BLOCK copolymers; RING-opening polymerization; ADDITION polymerization; CURCUMIN; DIBLOCK copolymers; COPOLYMER micelles; ETHYLENE glycol
- Publication
Macromolecular Chemistry & Physics, 2019, Vol 220, Issue 16, pN.PAG
- ISSN
1022-1352
- Publication type
Article
- DOI
10.1002/macp.201900210